| Drug | Pharmacokinetics | Considerations |
|---|---|---|
| Acyclovir |
|
Dosing
| Drug | Indication | Dosing |
|---|---|---|
| Acyclovir |
|
CrCl ⩾10: 2mg/kg Q12H IV |
| CrCl <10: 1mg/kg Q12H IV | ||
| IHD: 1mg/kg Q24H IV | ||
| CRRT: 2mg/kg Q12H IV | ||
|
CrCl ⩾50: 5mg/kg Q8H IV CrCl 50-25: 5mg/kg Q12H IV |
|
| CrCl 25-10: 5mg/kg IV OD | ||
| CrCl <10: 2.5mg/kg IV OD | ||
| IHD: 2.5mg/kg IV OD | ||
| CRRT: 5-10mg/kg Q12H IV | ||
|
CrCl ⩾50: 10mg/kg Q8H IV | |
| CrCl 50-25: 10mg/kg Q12H IV | ||
| CrCl 25-10: 10mg/kg IV OD | ||
| CrCl <10: 5mg/kg IV OD | ||
| IHD: 5mg/kg IV OD | ||
| CRRT: 10mg/kg Q12H IV | ||
| Ganciclovir |
|
CrCl >70: 5mg/kg Q12H IV |
| CrCl 50-70: 2.5mg/kg Q12H IV | ||
| CrCl 25-50: 2.5mg/kg Q24H IV | ||
| CrCl 10-25: 1.25mg/kg Q24H IV | ||
| CrCl <10: 1.25mg/kg 3×/week | ||
| IHD: 1.25mg/kg IV post HD | ||
| CRRT: 2.5mg/kg IV Q12-24H | ||
| Ganciclovir |
|
CrCl >70: 5mg/kg Q24H IV |
| CrCl 50-70: 2.5mg/kg Q24H IV | ||
| CrCl 25-50: 1.25mg/kg Q24H IV | ||
| CrCl 10-25: 0.625mg/kg Q24H IV | ||
| CrCl <10: 0.625mg/kg 3×/week | ||
| IHD: 0.625mg/kg IV post HD | ||
| CRRT: 1.25-2.5mg/kg IV Q12-24H | ||
| Oseltamivir |
|
CrCl >60: 75mg Q24H PO |
| CrCl 30-60: 30mg Q24H PO | ||
| CrCl <30: 30mg Q48H PO | ||
| IHD: 30mg PO load, then 30mg PO post every second IHD | ||
| CRRT: 75mg Q24H PO | ||
| Oseltamivir |
|
CrCl >60: 75mg Q12H PO |
| CrCl 30-60: 30mg Q12H PO | ||
| CrCl <30: 30mg Q24H PO | ||
| IHD: 30mg PO load, then 30mg PO post IHD | ||
| CRRT: 75mg Q12H PO | ||
| Valacyclovir |
|
CrCl >50: 1g Q8H PO |
| CrCl 30-50: 1g Q12H PO | ||
| CrCl 10-30: 1g Q24H PO | ||
| CrCl <10: 500mg Q24H PO | ||
| IHD: 500mg Q24H PO | ||
|
CrCl >30: 1g Q12H PO | |
| CrCl 10-30: 1g Q24H PO | ||
| CrCl <10: 500mg Q24H PO | ||
| IHD: 500mg Q24H PO | ||
| Valgancyclovir |
|
CrCl >60: 900mg Q12H PO |
| CrCl 40-60: 450mg Q12H PO | ||
| CrCl 25-39: 450mg Q24H PO | ||
| CrCl 10-24: 450mg Q48H PO | ||
| CrCl <10: 200mg 3×/week PO | ||
| IHD: 200mg PO post IHD | ||
| Valgancyclovir |
|
CrCl >60: 900mg Q24H PO |
| CrCl 40-60: 450mg Q24H PO | ||
| CrCl 25-39: 450mg Q48H PO | ||
| CrCl 10-24: 450mg 2×/week PO | ||
| CrCl <10: 100mg 3×/week PO | ||
| IHD: 100mg PO post IHD |
All CrCl values are given in mL/min.
References
- Balfour HH. Antiviral Drugs. New England Journal of Medicine. 1999 Apr 22;340(16):1255–68.