Hypokalaemia

Serum potassium level <3.5mmol/L, classified by magnitude into:

Epidemiology and Risk Factors

Pathophysiology

Aetiology

Causes include:

  • ↓ Potassium intake
    • Dietary
      <1g/day.
  • Redistribution
    • Alkalosis
    • Drugs
      • Insulin
      • β-agonism
  • ↑ Potassium loss
    • GI
      • Diarrhoea
      • Vomiting
      • Ileostomy
      • Fistulae
      • Villous adenoma
    • Renal
      • Hypomagnesaemia
      • Nephrogenic DI
      • Bartter’s syndrome
      • Liddle’s syndrome
      • Gitelman’s syndrome
    • Hyperaldosteronism
    • Drugs
      • Diuretics
      • Laxative abuse
      • Licorice
      • Steroids
    • RRT

Clinical Features

Assessment

History

Exam

Investigations

Bedside:

Laboratory:

Imaging:

Other:

  • ECG
    • ↑ P wave amplitude
    • Prolonged PR interval
    • ST depression, T-wave flattening or inversion
    • U waves

Diagnostic Approach and DDx

Management

Goals of management

Resuscitation:

Specific therapy:

  • Pharmacological
  • Procedural
  • Physical

Supportive care:

Disposition:

Preventative:

Marginal and Ineffective Therapies

Anaesthetic Considerations

Complications

Prognosis

Key Studies


References