Hypoxic-Ischaemic Encephalopathy

Epidemiology and Risk Factors

Pathophysiology

Aetiology

Clinical Manifestations

Diagnostic Approach and DDx

Investigations

Management

HIE Management Algorithm

Resuscitation:

ABC approach. Comment on team coordination and clinical priorities.

Specific therapy:

  • Pharmacological
  • Procedural
    • TTM
      For 1-2 days.
  • Physical

Supportive care:

Disposition:

Prognostication

Poor prognosis indicated at 72 hours post ROSC (and following rewarming) by the combination of:

  • Bilaterally absent pupillary reflexes
  • Bilaterally absent SSEP N20 peaks

Marginal and Ineffective Therapies

Anaesthetic Considerations

Complications

Prognosis

Key Studies


References