Conn’s Syndrome

Disease of aldosterone excess, which may be:

• Primary
  • Adrenal hyperplasia
  • Adrenal adenoma
    Bilateral in 30%.
• Secondary
  • Excess renin secretion
  • Hepatic disease
  • Cardiac failure

Epidemiology and Risk Factors

Pathophysiology

Aetiology

Clinical Manifestations

Features include:

• C
  • Hypertension
  • Cardiac failure
• F
  • Metabolic alkalosis
  • Hypokalaemia

History

Examination

Diagnostic Approach and DDx

Investigations

Management

Anaesthetic Considerations

• C
  • Hypertension
    Classically diastolic.
  • Cardiac failure
  • CHF
• E
  • Sensitivity to muscle relaxants
• F
  • Electrolyte abnormalities
    Hypokalaemia, alkalosis.

Marginal and Ineffective Therapies

Complications

Prognosis

Key Studies

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References